Synergistic activity of an OmpA inhibitor and colistin against colistin-resistant Acinetobacter baumannii: mechanistic analysis and in vivo efficacy

This study was supported by the Consejeria de Salud y Bienestar Social (PI12-0069), by the Consejeria de Economia, Innovacion, Ciencia y Empleo (CTS-6173/12) of Andalusia, Spain, by the Instituto de Salud Carlos III, Ministerio de Economia, Industria y Competitividad (PI15/01358), by Plan Nacional de I + D+i 2013‐2016 and Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0009), by Ministerio de Economia, Industria y Competitividad (Bio2016-75327-R) ‐ cofinanced by European Development Regional Fund ‘A way to achieve Europe’, Operative programme Intelligent Growth 2014‐2020, and by the Generalitat de Catalunya (XRB, 2017SGR0998 and 2014LLAV-00064). Y. S. is supported by the Subprograma Miguel Servet Tipo I from the Ministerio de Economia y Competitividad of Spain (CP15/01358). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain).