Selective Synthesis of 3-Methyleneindolin-2-ones by One-Pot Multicatalytic Processes.

2009 
A novel one-pot multicatalytic route for the synthesis of 3-methyleneindolin-2-ones has been developed involving sequential copper-catalyzed amination and palladium-catalyzed C–H functionalization processes. In the presence of CuI and Pd(OAc)2, a variety of propiolamides underwent the reaction with iodides to afford the corresponding 3-methyleneindolin-2-ones in moderate yields.
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