Papilledema of unknown cause

: Orbital metastases occur in 2-5 % of cancer patients. Common primary sites that cause orbital metastases are breast, lung and prostate cancer. In up to 25 % of patients orbital metastasis is the initial sign of an unknown primary tumor. Clinical symptoms are proptosis, ocular motility disorder and visual impairment. Imaging procedures may be useful in diagnosing orbital metastases but are not specific. Treatment is palliative. Radiotherapy, chemotherapy and surgical debulkment in selected patients are treatment options.