SYNTHETIC HUMAN GASTRIN-I AND GASTRIN-LIKE PENTAPEPTIDE IN STUDIES OF INTESTINAL-ABSORPTION IN MAN - ROLE OF GASTRIN IN HUMAN INTESTINAL-ABSORPTION

The effects of synthetic human gastric I (SHG I) and gastrin-like pentapeptide (PG) on jejunal water, electrolyte, and glucose absorption were studied in 11 normal subjects. The i.v. administration of graded doses of SHG I increased plasma gastrin levels similar to those after food intake and in the Zollinger-Ellison syndrome. SHG I and PG caused no significant changes in the net movement of water and solute. The findings indicate that gastrin has no direct effect on intestinal absorption in normal man, and does not account for the mechanism of diarrhea in the Zollinger-Ellison syndrome.