Сравнительная оценка эффективности лозартана (лозап) и кандесартана (атаканд) у больных с артериальной гипертензией по влиянию на суточный профиль артериального давления

To assess the comparative effectiveness of antihypertensive therapy by an angiotensin receptor antagonist Losartan or Candesartan in patients with uncontrolled ambulatory arterial hypertension (AH). Design and methods. The study included 60 patients aged from 35 to 65 years divide into two groups. The first group included 31 hypertensive patients (15 men and 16 women, mean age 46,1 ± 9,9 years) receiving losartan. The second group was formed by 29 patients (12 men and 18 women, mean age 47,2 ± 9,8 years) with long-term hypertension receiving candesartan. Hypertension was diagnosed based on history and results of clinical and instrumental examination: blood tests, urinalysis, electrocardiogram, echocardiography, repeated 24-hour monitoring of blood pressure (BP) («BPLab» MnSDP-2) (at baseline and 4 weeks after drug administration). Results. Candesartan has significant benefits over losartan on the effect on circadian BP profile (reduction of the daily index of systolic BP by 5,8 and 4,8 % respectively, p