Disseminated Equine Herpesvirus-1 Infection in a Two-Year-Old Filly

emus infected with WEE were depression, loss of appetite, leg weakness, ataxia and side stepping in an effort to maintain balance. The prominent gross lesion observed was congestion of the blood vessels of the viscera, meninges, and brain. The significant histologic lesion observed was multifocal meningitis with mild axonal degeneration. In reported cases of EEE, 7 most birds died without premonitory signs. However, a severe hemorrhagic diarrhea and emesis of blood-stained ingesta was observed terminally in some birds. Gross lesions were reported to be petechial to ecchymotic serosal hemorrhages in the small and large intestines with unclotted or partially digested blood in the intestinal lumina. Consistent microscopic lesions in EEE 7 were diffuse congestion and hemorrhage in the liver with disruption of the hepatic cords, widespread necrosis of individual hepatocytes, and multifocal coagulative necrosis. Fibrinoid degeneration of splenic sheathed arterioles with necrosis of endothelial a.