Variations in the rate of synthesis of beta and beta' RNA polymerase polypeptides under the influence of certain factors.

In merodiploid cells containing a double dose of structural genes of RNA polymerase subunits-rpoBand rpoC-the rate of β and β′ subunits synthesis is 2 times higher than in haploidcells. Missence mutation rpoC1 (tsX) alters β′ polypeptide and inducesthe β and β′ subunits synthesis at increased rate, particularly at a nonpermissive temperature. When rpoBCoperon carrying mutation rpoC1 is duplicated no dosage effect is observed. In the rpoC+/rpoC1 heterodiploid the rpoC1 mutation does not significantly accelerate RNA polymerase subunits synthesis i.e. is recessive with respect to rpoC+