EpigeneticSilencingof-Spectrin,aTGF-Signaling/Scaffolding Protein in a Human Cancer Stem Cell Disorder

Zhi-Xing Yao, Wilma Jogunoori, Sanaa Choufani, Asif Rashid, Tiffany Blake, Wenguo Yao, Peter Kreishman , Rupen Amin, Anton A. Sidawy**, Stephen R. T. Evans, Milton Finegold, E. Premkumar Reddy, Bibhuti Mishra, Rosanna Weksberg, Rakesh Kumar , and Lopa Mishra From the Departments of Gastroenterology, Hepatology, and Nurition and Pathology, M. D. Anderson Cancer Center, Houston, Texas 77030, the Department of Surgery, Georgetown University, Washington, D. C. 20057, the Department of Biochemistry and Molecular Biology, George Washington University, Washington, D. C. 20037, the Department of Pathology, Baylor University, Houston, Texas 77030, the **Department of Veterans Affairs Medical Center, Washington, D. C. 20422, Mount Sinai Medical Center, New York, New York 10029, the Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada, and the Walter Reed Army Medical Center, Washington, D. C. 20307