ИНТРАОПЕРАЦИОННАЯ ФОТОДИНАМИЧЕСКАЯ ТЕРАПИЯ БОЛЬНЫХ РАКОМ ЖЕЛУДКА

Results of intraoperative photodynamic therapy (IOPDT) in patients with gastric cancer are represented in the article. The study included 240 patients with gastric cancer stage II-IV (Т3-4N0-3M0-1) with  evident or suspected peritoneal dissemination who underwent  examination and treatment in P.Herzen Moscow Oncology Research  Institute. The group 1, the study group, included 140 patients who  underwent nominally curative or palliative surgery for locally  advanced and disseminated gastric cancer with IOPDT as additional  intraoperative intervention for antiblastics and cancer treatment. The group 2, the control group, included 100 patients who also  underwent nominally curative or palliative surgery (equal to extent  of surgery in patients from the study group) for locally advanced and disseminated gastric cancer and no intraoperative implication of physical or chemical treatment methods. IOPDT did not worsen a course of early post-operative period, did not impact on severity of  post-operative complications and was not associated with increase of post-operative mortality. IOPDT allowed for improvement of 1-year  and 3-year disease-specifi c survival rates: by 16.1% and 16.7%,  respectively. For nominally curative resections, median survival, 1- year and 3-year disease-specifi c survival rates were improved by 14 months, 17.8% and 31.3%, respectively. For R1, R2 resections,  IOPDT improved 1-year disease-specifi c survival rates by 16.4%. Additionally, for nominally curative resections IOPDT did not increase the recurrence rate and improved median recurrence-free survival,  1-year and 3-year recurrence-free survival rates by 16 months,  27.2% and 25.4%, respectively.