Effects of neurotropin on pain syndromes of various etiology

Abstract The effects of neurotropin have been studied on a model of a neuropathic pain syndrome caused by sciatic nerve injury as well as on a model of the adjuvant arthritis pain syndrome caused by Freund's adjuvant injected into the plantar region of the lower limb. The experimental results suggest that neurotropin prevents the development of the neuropathic pain syndrome in many cases and relieves the pathological process in the already developed syndrome. However, neurotropin fails to prevent the development of adjuvant arthritis but markedly decreases its severity. Neurotropin normalized the thresholds of pain sensitivity upon thermal stimulation (`hot plate' method) which remain at a sufficiently high level also after cessation of neurotropin injections. The analgetic action of neurotropin is due to its suppressive effect on various links of the pathologic algic system.