The effects of freeze-dried mango on bone parameters of ovariectomized mice (1025.9)

Osteoporosis is a major problem worldwide particularly in postmenopausal women. Interest is growing in dietary alternatives, such as fruits and vegetables, in treating and/or preventing osteoporosis in this population. Mango is an excellent source of dietary antioxidants, such as ascorbic acid, carotenoids, and phenolic compounds, which can play a role in maintaining bone health. The objective of this study was to investigate the effects of two doses of mango and its polyphenol (PP) in preventing bone loss in ovariectomized (Ovx) mice, a model of postmenopausal osteoporosis. Ninety, female three-month-old C57/ BL6 mice were either sham-operated or Ovx and were randomly assigned to one of the following treatment groups for ninety days (n=12/group): (a) Sham+control, (b) Ovx+control, (c) Ovx+1% or 10% (w/w) freeze-dried mango or mango PP diet (equivalent PP to that of 1 and 10% mango), and (d) Ovx+alendronate (ALN) injection (1 ug/kg body weight). All diets were isocaloric, isonitrogenous and had the same c...