Impact of the cosmetic mouthwash "Jack Pro Spülung plus" ("rheodol-Spülung plus") on the oral cavity flora, tested in a monocentric, controlled, randomized, blind, cross-over comparative study.
2014
Aim: Jack Pro Spulung Plus (also available as “rheodol-Spulung plus”) is recommended to mechanically maintain oral hygiene as part of an overall oral hygiene concept. Because Jack Pro Spulung Plus contains the active agents polihexanide and tosylchloramide sodium in concentrations below microbicidal efficacy, this study tested the hypothesis that the combination of mechanical rinsing and bacteriostatic effect surpasses the effect of mechanical rinsing alone.
Method: The study was performed with 30 volunteers as a monocentric, controlled, randomized, blind, cross-over comparative study. The efficacy of the test product (active agents polihexanide 0.02–0.03% and tosylchloramide sodium 0.004–0.006%) was compared to an aqueous solution of polihexanide (0.02–0.03%) and to Ringer solution as negative control. The efficacy was measured as the reduction of colony forming units (cfu) on buccal mucosa after aerobic and anaerobic cultivation. After determination of pre-values, the volunteers performed mouthrinsing for 30 sec with each of the 3 tested solutions. After 1, 10 and 60 minutes, cfu numbers were determined again. The reduction factor was calculated as the difference between log10 of the measured cfu before and after mouthrinsing with the test solution. The sampling was performed using a template with a smear area of 1 x 1 cm.
Results: Using Ringer solution led to a slight mechanically-induced reduction of cfu in the oral cavity 1 min after rinsing the mouth cavity with the solution. After 10 min and 60 min, no influence on the cfu number could be detected. Using Jack pro Spulung Plus led to a bacteriostatic effect up to 60 min after mouthrinsing; 10 min and 60 min after rinsing the efficacy of Ringer solution was also significantly surpassed. The aqueous solution of polihexanide was less effective than Jack pro Spulung Plus after 10 and 60 min.
Conclusion: Based on these observations, we conclude that Jack pro Spulung Plus is suitable for improvement of oral hygiene if patients have sensitive oral mucosa, e.g., in cases of aggressive cancer therapy or for patients with tracheostoma.
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