Altered Vascular Phenotype in Autism

Setting and Subjects: Children with a clinical diagnosis of autism attending the Pfeiffer Treatment Center. Results: Compared with controls, children with autism had significantly higher urinary levels of isoprostane F2-VI, 2,3-dinor-thromboxane B2, and 6-ketoprostaglandin F1. Lipid peroxidation levels directly correlated with both vascular biomarker ratios. Conclusion: Besides enhanced oxidative stress, platelet and vascular endothelium activation also could contribute to the development and clinical manifestations of autism.