Synthesis, and molecular docking stimulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages

: Novel bis(1,4-dihydropyridine-3,5-dicarbonitrile) derivatives linked to arene core via amide or ester-amide linkages were prepared and their structures were confirmed by several spectral tools. The synthesis of novel N,N'-(alkanediyl)bis(2-(2-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetamide) by an acid-catalyzed condensation of the bis-aldehydes with four equivalents of 3-aminocrotononitrile was reported. The structures of the synthesized compounds were confirmed by the different spectral tools. The molecular docking stimulation studied indicated that, the prepared compounds are promising bioactive molecules.