Inhibitor of β-Hydroxy-β-Methylglutaryl Coenzyme A Reductase Decreases Energy Supply to the Myocardium in Rats

Hypocholesterolemic preparations, inhibitors of the key enzyme of cholesterol biosynthesis β-hydroxy-β-methylglutaryl coenzyme A reductase (statins), block the synthesis of ubiquinone Q10, intermediate electron carrier in the mitochondrial respiratory chain. This should decrease energy supply to tissues. Daily peroral administration of β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor simvastatin (24 mg/kg perorally) for 30 days had no effect on the contents of macroergic phosphates (ATP and creatine phosphate) in the liver, but decreased these parameters in the myocardium.