Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases.

Andrew Jobson,Elaine Willmore,Michael J. Tilby,Prakash Mistry,Peter Charlton,Caroline A. Austin

Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases.

2009

Andrew Jobson
Elaine Willmore
Michael J. Tilby
Prakash Mistry
Peter Charlton
Caroline A. Austin

Purpose Previous in vitro cleavage data showed that XR11576 and XR5944 stabilised topoisomerase I and topoisomerase II complexes on DNA in a dose-dependent fashion. However, some studies indicated a possible topoisomerase-independent mechanism of action for these drugs.

Keywords:

Biochemistry
Topoisomerase
DNA repair
Phenazine
Topoisomerase-II Inhibitor
Topoisomerase-I Inhibitor
DNA
DNA damage
Mechanism of action
Biology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations