Medicinal chemistry of nucleic acids

FOREWORD vii CONTRIBUTORS xi INTRODUCTION xv 1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY 1 Jianing Wang, Ravindra K. Rawal, and Chung K. Chu 2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES 101 Wen Zhang, Jia Sheng, and Zhen Huang 3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 142 Hon Cheung Lee 4 DNA AND RNA BINDING SMALL MOLECULES 164 Shibo Li and Zhen Xi 5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY 206 Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and Lian-Quan Gu 6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN 258 Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang 7 STRUCTURE OF 10 23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME 272 Oleksandr Plashkevych and Jyoti Chattopadhyaya 8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE 292 Il Joon Lee and Byeang Hyean Kim 9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS 335 Rakesh N. Veedu and Jesper Wengel 10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349 Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao, Caihong Liu, and Ying Wang 11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390 Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng, Qiu-Chen He, Li-He Zhang, and De-Min Zhou 12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405 Quan Du, Huang Huang, and Zicai Liang INDEX 423