Administration of granulated BCAA and quality of life.

The PEM (protein energy malnutrition) is an important factor for improvement of prognosis and QOL in the patients with liver cirrhosis. In 453 chronic liver disease patients, QOL decreased significantly according to the progression of disease assessed by SF-36 (Kruskal-Wallis test: p < 0.05) Moreover, the QOL of patients with chronic liver diseases was improved in BCAA administration group (n = 13) compared with non-administration group (n = 12) after 6 months period. In conclusion, BCAA administration showed improvement of PEM and QOL of patient with chronic liver diseases.