Utility of genetic and non-genetic risk factors in predicting coronary heart disease in Singaporean Chinese

BackgroundAlthough numerous phenotype based equations for predicting risk of ‘hard’ coronary heart disease are available, data on the utility of genetic information for such risk prediction is lacking in Chinese populations.DesignCase–control study nested within the Singapore Chinese Health Study.MethodsA total of 1306 subjects comprising 836 men (267 incident cases and 569 controls) and 470 women (128 incident cases and 342 controls) were included. A Genetic Risk Score comprising 156 single nucleotide polymorphisms that have been robustly associated with coronary heart disease or its risk factors (p < 5 × 10−8) in at least two independent cohorts of genome-wide association studies was built. For each gender, three base models were used: recalibrated Adult Treatment Panel III (ATPIII) Model (M1); ATP III model fitted using Singapore Chinese Health Study data (M2) and M3: M2 + C-reactive protein + creatinine.ResultsThe Genetic Risk Score was significantly associated with incident ‘hard’ coronary heart dise...