HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity
2013
Background
Current HIV-1 envelope glycoprotein (Env) vaccines are unable to induce cross-reactive neutralizing antibodies. However, such antibodies are elicited in 10-30% of HIV-1 infected individuals, but it is unknown why these antibodies are induced in some individuals and not in others. We hypothesized that the Envs of early HIV-1 variants in individuals who develop cross-reactive neutralizing activity (CrNA) might have unique characteristics that support the induction of CrNA.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
131
References
33
Citations
NaN
KQI