In vitro inhibition of human lymphocyte transformation by natural or synthetic prostaglandins

Abstract We have examined the role of 45 natural or synthetic prostaglandins (PGs) in the in vitro responsiveness of human lymphocytes toward two different varieties of mitogenic stimuli : the mixed lymphocyte culture (MLC) and the tuberculinic test (TT). Addition of PGs to culture of lymphocytes decreases the uptake of H thymidin.