Synthesis and Evaluation of 3-Substituted l-[4-(2-Indol-3-ylethyl)piperazinyl]ureas as Potential Antihypertensive Agents

Abstract A series of 3-substituted l-[4-(2-indol-3-ylethyl)piperazinyljureas was synthesized and screened for antihypertensive activity in spontaneously hypertensive rats. Two compounds with aryl urea substituents were very potent and lowered blood pressure 55 mm or more at oral doses of 100 mg/kg. However, both compounds failed to produce a cardiovascular response in the normotensive dog.