Abstract 18729: Blood Pressure Trajectories, Carotid Artery Intima-Media Thickness and Left Ventricular Mass: Results From a 23-Year Longitudinal Study From Childhood to Young Adulthood

Background: The aims of this study were to identify subgroups of individuals with similar trajectories in blood pressure (BP) from childhood to adulthood, and to determine the relationship of BP trajectories with the carotid intima-media thickness (IMT) and left ventricular mass (LVM). Methods: BP were measured up to 16 times over a 23-year period in 683 participants who were 5-38 years old. BP trajectories were modeled using latent class models. At the visit 12, 14 and 15, IMT and LVM were measured in 551 participants (1215 measurements) and 546 participants (1229 measurements) respectively. Mixed linear regression models were used to evaluate the association of BP trajectories with IMT and LVM controlling for other covariates. Results: Three trajectory groups (high-increasing (HI), moderate-increasing (MI) and low-increasing (LI) group) in BP from childhood to adulthood were identified. We found that trajectories of systolic blood pressure (SBP) was a significant predictor of IMT (P=0.007 for MI group and P =0.012 for HI group compared with LI group) and LVM (P=0.008 for MI group and P =0.012 for HI group compared with LI group). Increased IMT and LVM were associated with the increased rate of growth in SBP (P for trend Conclusion: Our results suggested that different BP trajectories exist from childhood to adulthood, and the trajectories were independently associated with the IMT and LVM. We first time reported that SBP trajectories during childhood were significantly associated with subclinical cardiovascular indices, indicating that monitoring trajectories of BP from childhood may have potential for identifying high cardiovascular risk population as early in life as possible.