B-cell lymphoma: Suppressing a tumor suppressor

Alexander Dent

B-cell lymphoma: Suppressing a tumor suppressor

2005

Alexander Dent

The BCL-6 oncogene can downregulate expression of the p53 tumor suppressor gene in B cell lymphoma. This pathway probably exists to protect normal germinal-center B cells from apoptosis induced by DNA mutations.

Keywords:

B-cell lymphoma
Immunology
Suppressor
DNA
Oncogene
P53 tumor suppressor gene
Apoptosis
Downregulation and upregulation
B cell
Medicine
dna mutation

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