Neighboring Thioether Participation in Bioinspired Radical Oxidative C(sp3)-H α-Oxyamination of Pyruvate Derivatives.

A bioinspired radical oxidative α-oxyamination of pyruvate with an oxoammonium salt through multiple-site concerted proton-electron transfer process has been developed, which was facilitated by anchoring the mercapoto chains as a "hopping" site at the γ-position of α-keto esters.