The analysis of cephalosporin antibiotics on Acinetobacter baumannii in the intensive care unit.

Objective To investigate the resistance of cephalosporin antibiotics in Acinetobacter baumannii and the main genotypes of beta-lactamases in the Liaocheng district. Methods The Kirby-Bauer method was used to detect the resistance to six kinds of antimicrobial agents against 120 strains of A. baumannii. The main genotypes of beta-lactamases were assayed by PCR. Results Among the 70 strains of A. baumannii, the resistance rate to cefoperazone/sulbactam was 7.1%, the resistance rate to ceftriaxone was 65.0%, and the resistance rates to cefepine and ceftazidime were 61.7% and 64.2%, respectively. The resistance rates to cefazolin and cefuroxime were more than 80.0%. TEM type beta-lactamase genes were positive in all of the 80 isolates tested, which were multi-drug-resistant. The GES type beta-lactamase were positive in two strains, and the VEB type was founded in one strain. CARB, DHA and PER genes were not found in any isolates tested. Conclusion In the Liaocheng district, the TEM type beta-lactamase is the main type in A. baumanniss and is related to high-resistance to the beta-lactamase antibiotics.