Influence of the Nuclear Membrane, Active Transport, and Cell Shape on the Hes1 and p53–Mdm2 Pathways: Insights from Spatio-temporal Modelling

There are many intracellular signalling pathways where the spatial distribution of the molecular species cannot be neglected. These pathways often contain negative feedback loops and can exhibit oscillatory dynamics in space and time. Two such pathways are those involving Hes1 and p53–Mdm2, both of which are implicated in cancer.