Rapid scan microvoltammetric detection for liquid chromatography

Abstract A carbon microvoltammetric electrode has been used as the working electrode in a rapid scan detector for high-performance liquid chromatography (HPLC). Analytes are detected by the 9 um carbon fiber as they elute into a cell. Effects of scan rate and flow rate are discussed. Detection limits of 10−6 M (1.1 ng, injected) have been obtained for hydroquinone, and the detector is linear over four orders of magnitude in concentration. The two-dimensional resolving power is demonstrated using a nurture of six standards and the detector is used for the identification of caffeine in tea.