Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.

Amelia Escolano,Harry B. Gristick,Rajeev Gautam,Andrew T. DeLaitsch,Morgan E. Abernathy,Zhi Yang,Haoqing Wang,Magnus A.G. Hoffmann,Yoshiaki Nishimura,Zijun Wang,Nicholas Koranda,Leesa M. Kakutani,Han Gao,Priyanthi N. P. Gnanapragasam,Henna Raina,Ana Gazumyan,Melissa Cipolla,Thiago Y. Oliveira,Victor A. Ramos,Darrell J. Irvine,Murillo Silva,Anthony P. West,Jennifer R. Keeffe,Christopher O. Barnes,Michael S. Seaman,Michel C. Nussenzweig,Malcolm A. Martin,Pamela J. Bjorkman

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.

2021

Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody coevolution. Previous studies showed that sequential immunization with a V3-glycan patch germline-ta...

Keywords:

Antibody
Heterologous
Glycan
human immunodeficiency virus
immunization
Biology
Virology
Virus

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