Asymmetric synthesis of trans-(2R,5R)-bis(benzyloxymethyl)pyrrolidine
1989
Abstract Trans-(2R,5R)-bis(benzyloxymethyl)-pyrrolidine ( 1 ) was prepared from 1,2:5,6-diisopropylidene mannitol. Key transformations included the selective protection of primary hydroxy groups and stereocontrolled cyclization.
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