Self-based composition microemulsificável, microemulsion and preparation method of the self-base composition microemulsificável

BASE COMPOSITION AUTOMICROEMULSIFICaVEL, microemulsion and METHOD OF PREPARATION BASE COMPOSITION AUTOMICROEMULSIFICaVEL. The invention provides a method and composition for enhancing the properties of dissolution and bioavailability of propofol (2, 6-diisopropyl phenol) for use as an intravenously administered anesthetic I mammals. The method produces a composition based microemulsificavel self-emulsion, which is used in the production of a preparation of microemulsion based on water. In a base composition of two (2) preferred components, the base composition consists of a surfactant. gricol which contains polyethylene; and liquid propofol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 4% by weight of propofol compared to the volume of the microemulsion. In a base composition of four (4) components, the base composition consists of: a surfactant, which contains polyethylene glycol; liquid propofol; a solvent immiscible in water; and ethanol. The microemulsion is prepared by mixing the base composition with a carrier liquid, which results in the formation of a microemulsion containing concentrations of propofol of up to about 10% by weight of propofol compared to the volume of the microemulsion.