Zollinger-Ellison syndrome: Clinical and histopathologic manifestations☆
1969
Abstract Zollinger-Ellison syndrome is caused by a neuroendocrine tumor of the pancreas that secretes gastrin, causing massive gastric acid secretion. Treatment of the acid hypersecretion may be accomplished with pharmacologic acid inhibition. The goal of surgical treatment should be removal of all gross tumor in those without distant metastases. Cure rates approximate 30% and 20-year survival exceeds 70% even without cure.
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