Lokal vávsbeskadigelse efter intramuskulár injektion af neuroleptika

Various therapeutic agents for intramuscular injection cause local muscle damage at the injection site in animals. Indirect evidence (increase of serum creatine kinase (CK) levels) suggests that some of these drugs also cause local muscle damage in patients. The present study with pigs was carried out in order to investigate the tissue at the injection site after intramuscular injection of commercially available aqueous preparations of chlorpromazine, perphenazine, haloperidol and the new neuroleptic formulation zuclopenthixol acetate in Viscoleo. Muscle damage was quantified three days after intramuscular injection (2 ml) by weighing the damaged tissue and by determining the loss of CK from this same tissue. The aqueous neuroleptics produced a marked lesion composed of a demarcated region of necrotic muscle tissue. The loss of CK activity was marked (5.6–7.6 g). After injection of zuclopenthixol acetate only a few grey stripes were seen and only 0.2 g of muscle tissue had lost its CK activity. Thus where...