Влияние кратковременной глюкозной депривации на функционирование нейронной сети первичной культуры гиппокампа на мультиэлектродной матрице

There has been studied the effect of a short-term glucose deprivation on neuron net functioning of hippocampus primary culture developing within 32 days on a multi-electrode matrix MED64 (Alpha MED Sciences Company, Japan) in an early and remote periods after deprivation. A short-term glucose deprivation (20 min) has been shown to result in the increase of electrobiological activity of neuron net of hippocampus primary culture, with the cascade of metabolic reactions being activated leading to the death of functional neuron thereafter. In a remote period the simplification of a functional structure of neuron net occurs, with node control units being preserved. A short-term glucose deprivation creates an effect of metabolic preconditioning that in a remote period prevents a neuron net from permanent morphofunctional damages during the longer glucose deprivation.