In vitro activity of fleroxacin in combination with other antimicrobial agents.

The trifluoroquinolone fleroxacin inhibits the majority of Enterobacteriaceae at concentrations ≤1 μg/mL and most Pseudomonas aeruginosa and staphylococci at ≤2 μg/mL. The purpose of this study was to determine the effect of the combination of fleroxacin with other antimicrobial agents. Previous studies that used checkerboard assay, fixed concentrations, and killing curves were reviewed, and these methods were used to evaluate the combination of fleroxacin and agents that had not been previously studied