Composite substrate and a method of manufacturing the same, including silk and collagen

Embodiments of the present invention by providing a structure which replaces the tissue, or include that at least one of the woven silk tube layer and the collagen layer of the inner tube of the biodegradable support, and a method of producing a guided tissue regeneration, tissue and not only superior in terms of mechanical properties, it does not substantially cause an immune reaction after transplantation can be effectively used as a substrate for the ligament and muscle reconstruction results when playing, muscle damage.