Bispectral Index Monitoring during Sedation with Sevoflurane, Midazolam, and Propofol

(PK 5 0.87 6 0.11, 0.76 6 0.01, and 0.69 6 0.02, respectively; P < 0.05). At 10 min after the procedure, 76, 48, and 24% of sevoflurane, propofol, midazolam patients, respectively, returned to baseline Digit Symbol Substitution scores (P < 0.05). Excitement‐disinhibition occurred in 70, 36, and 5% of sevoflurane, propofol, and midazolam patients, respectively (P < 0.05). Conclusion: Individual BIS scores demonstrate significant variability, making it difficult to predict sedation depth. The relation between BIS and sedation depth may not be independent of anesthetic agent. Quality of recovery was similar between drugs, but excitement occurred frequently with sevoflurane. THE Bispectral Index (BIS) has been used as a measure of the hypnotic effects of anesthetic agents. Although more commonly used as a measure of hypnosis during general anesthesia, BIS has also been used during sedation. BIS has been used to evaluate depth of sedation with propofol, 1,2 midazolam, 3 and sevoflurane. 4,5 Specifically, BIS has been evaluated for its ability to predict response to