ENDOTHELIAL DYSFUNCTION PRECIPITATED BY TRANSFUSION OF STORAGE–AGED BUT NOT FRESH RED BLOOD CELLS

Robert Neuman,Vivek Menon,Sulaiman Karatela,James L. Newman,Salman Sher,Khuram Ashraf,Jose Binongo,John D. Roback,Arshed A. Quyyumi

ENDOTHELIAL DYSFUNCTION PRECIPITATED BY TRANSFUSION OF STORAGE–AGED BUT NOT FRESH RED BLOOD CELLS

2013

Robert Neuman
Vivek Menon
Sulaiman Karatela
James L. Newman
Salman Sher
Khuram Ashraf
Jose Binongo
John D. Roback
Arshed A. Quyyumi

Transfusion of storage–aged (aged) packed red blood cells (pRBCs) is associated with worse outcomes, but the underlying mechanisms remain unknown. We tested endothelial nitric oxide (NO) bioavailability during transfusion of aged and fresh pRBCs with the hypothesis that aged pRBCs will impair

Keywords:

Diabetes mellitus
Endothelial dysfunction
Internal medicine
Medicine
Cardiology
Packed red blood cells
Pharmacology
Immunology
Bioavailability
endothelial nitric oxide

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