Clinical guidelines on isoniazid preventive therapy for patients with silicosis in South Africa : issues in OH

Clinical guidance on the treatment of latent tuberculosis in people with silicosis is provided. This guideline, developed during a workshop held in July 2013, is particularly applicable to resource-constrained, tuberculosis endemic settings and has been aligned with World Health Organization and South African National Department of Health guidelines for the treatment of latent tuberculosis infection. Major changes from the previous guideline include 1) utilization of tuberculin skin testing to guide treatment of latent tuberculosis; and 2) the increase of the duration of isoniazid treatment to 36 months.