Curative effect comparison of Minocycline Hydrochloride Ointment and lodine glycerin on acute gingivitis

Objective To discuss curative effect comparison of Minocycline Hydrochloride Ointment and lodine glycerin on acute gingivitis of rats. Methods 70 cases of patients with acute gingivitis were selected and divided into observation group(35 cases) and control group(35 cases) by table of random number, who were given the medical treatment outpatient Department of Stomatology in the First People's Hospital of Taizhou City from September 2012 to May 2013.The patients in two groups were given 3% superoxol and physiological saline, washing blind bag for gingivae with alternate repetition until the flushing fluid was clear enough, which was dried afterwards. The patients in observation group were additionally given Minocycline Hydrochloride Ointment, filled in the periodontal pocket, once for every two days until the recovery, while the patients in control group were given 3% lodine glycerin, filled in the periodontal pocket,once a day until the recovery. The inflammation subsided time and duration of pain of patients in two groups after the medical treatment were observed and recorded, and the clinical curative effect and drug adverse reaction(DAR) 5 days after the medical treatment were compared as well. Results The time alleviating pain and inflammation subsided time of patients in observation group after the medical treatment [(1.87±0.43),(3.52±0.73) d] were obviously short than those in control group [(2.94±0.67),(4.87±0.97) d], with statistical differences(t = 2.43, 2.27, P 0.05). After 5 days' medical treatment, the recovery rate of patients in observation group was 65.71%, which was much higher than that in control group(40.00%)(χ2=4.65, P 0.05). The total clinical efficiency of patients in observation group was 94.29%,which was much higher than that in control group(71.43%)(χ2=6.44, P 0.05). No obvious DAR and allergic reaction occurred on patients in two groups during the medical treatment, and the maxillofacial cellulitis, osteomyelitis of jaw and other complications. Conclusion Compared with 3% lodine glycerin, Minocycline Hydrochloride Ointment has more favorable curative effect on acute gingivitis of rats, which can obviously shorten time of pain, speed the inflammation resolution, with convenient operation and high security, reduce the times of subsequent visit and be a safe and effective local slow-released drug to treat acute gingivitis of rats.