Effect of Tranilast on Proliferation, Collagen Gel Contraction, and Transforming Growth Factor Beta Secretion of Retinal Pigment Epithelial Cells and Fibroblasts

Tsutomu Yasukawa,Hideya Kimura,Jin Dong,Yasuhiko Tabata,Hideki Miyamoto,Yoshihito Honda,Yuichiro Ogura

Effect of Tranilast on Proliferation, Collagen Gel Contraction, and Transforming Growth Factor Beta Secretion of Retinal Pigment Epithelial Cells and Fibroblasts

2002

Tsutomu Yasukawa
Hideya Kimura
Jin Dong
Yasuhiko Tabata
Hideki Miyamoto
Yoshihito Honda
Yuichiro Ogura

The efficiency of tranilast for the treatment of proliferative vitreoretinopathy (PVR) was investigated in vitro. A tetrazolium-based colorimetric assay showed that the 300-µ M conce

Keywords:

Anatomy
Tranilast
Biology
Bovine serum albumin
Transforming growth factor-beta secretion
Transforming growth factor beta
Proliferative vitreoretinopathy
Retinal
Transforming growth factor
Internal medicine
Endocrinology
In vitro
collagen gel contraction
Diabetes mellitus
Pigment

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