Construction of Ultrasensitive Devices for Visualization and Quantification of Phosgene based on FRET-mediated Two-Photon chemosensor

Abstract As a widely used but highly toxic chemical species, phosgene is threatening to human health because of possible accidental leakage during industrial manufacture. Herein, we exploited a turn-on fluorescent sensor F671 for phosgene detection. The exact distance of nitro benzoxadiazole (NBD) and boron dipyrromethene (BODIPY) in F671 was changed from 5.027 A to 15.535 A after reaction with phosgene, accompanied with obvious fluorescence enhancement, which is attributed to the inhibition of Forster resonance energy transfer (FRET) process. The FRET-associated strategy possesses the capacity of detecting phosgene with a rapid response time (