Silencing expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis

Changes in expression and activation of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). Here we examined the expression of each Ras protein in the synovial tissue of patients with RA and disease controls and the contributions of H-, K- and N-Ras homologues to FLS activation in vitro and experimental arthritis in vivo. Synovial Ras …