Glatiramer acetate-specific human CD8+ T cells: Increased IL-4 production in multiple sclerosis is reduced by glatiramer acetate treatment

Abstract Glatiramer acetate (GA) is an approved drug for therapy of relapsing remitting MS that acts as a T cell antigen. Here, we report the cloning of HLA restricted, GA-specific human CD8+ T cells. In addition, we analyzed the cytokine profile of GA-reactive CD8+ T cell lines. Unexpectedly, IL-4 was increased in untreated MS patients as compared to healthy individuals ( p p p p