Priprava poroznih peleta kao nosača lijeka

With the advancement of new drug delivery systems, development of medicines to regulate cardiac arrhythmia has also occurred. New drug delivery systems improve dosage, help treat chronic conditions, reduce side effects, and dosage frequency. Research into pellets as carriers of such drugs is inspired by various benefits, both therapeutic and technological, as their multiparticulate nature offers many benefits in terms of conventional forms of treatment. In this paper, the research has been carried out in several steps and consists of the preparation of pellets, their characterization, and application of drug onto pellets as well as determination of drug content. The release rate and profiles of the active substance were determined. Dissolution profiles were described by the kinetic model. Pellets of microcrystalline cellulose were prepared with 70 % of NaCl in order to achieve satisfactory pellet porosity. Dronedarone hydrochloride was applied onto pellets by vacuum impregnation and immersion into solution. Pore size distribution and micrographs showed that porous pellets were obtained. Comparison of the amount of dronedarone applied by vacuum impregnation and immersion in an ethanol solution showed higher content of dronedarone in pellets obtained by vacuum impregnation. However, there is no significant difference in dissolution profiles from these pellets. Higher concentrations of solution were achieved by dissolving dronedarone in methanol, and by vacuum impregnation, up to 31.63 % of dronedarone was applied on pellets. By increasing the content of dronedarone in the pellets, the release rate increases as a result of the larger amount of dronedarone on the surface of the pellet. Dissolution profiles are described by the Peppas-Sahlin model, and the resulting model parameters show that the dominant release mechanism is diffusion. The results show that prepared pellets have potential as drug carriers for regulating cardiac arrhythmia.