Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex

Abstract The dinuclear complex bis[(μ 2 -chloro)chloro(1,10-phenanthroline)copper(II)] ( 1 ) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of ( 1 ) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex ( 1 ) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC 50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex ( 1 ) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.