The relationship between acute peritoneal infection with insulin resistance and the action window time of inflammatory factors

Objective To study the correlation of early glucose metabolism and inflammatory factors in rats with acute peritoneal infection.Methods Rats were randomly divided into 4 groups:A group,rats subjected to cecal ligation plus puncture(CLP);B group,to intraperitoneal injection of lipopolysaccharide(LPS);C group,to CLP combined with intraperitoneal injection of LPS C;D group,control group.A、B、C group all were to produce acute peritoneal infection.The blood glucose,TNF-α and IL-6 and insulin were detected,and insulin resistance index(IRI) was calculated to evaluate the extent of insulin resistance.Results Blood glucose level and IRI were elevated in the early stage in A、B、C groups,and reached a peak level at 6 h.IRI changes in the early stage had a positive correlation with TNF-α and IL-6.The rats that received LPS injection presented(B、C groups) mainly had a higher level of IL-6.And 1L-6 evaluated persisted longer than TNF-α did.Conclusions Our results suggest that insulin resistance can occur in the early stage of acute peritoneal infection.Although differences exist in their action time,both TNF-α and IL-6 have a positive relationship with insulin resistance.