Interaction of the Dopaminergic and Vasopressinergic Systems in Sleep Deprivation in Rats

Rats were subjected to 6-h sleep deprivation and were given three injections of the dopamine D1 receptor blocker SCH 39166. Immunohistochemical investigations revealed increases in D1 and D2 dopamine receptor and glutamate immunoreactivity on the background of sleep deprivation and a 2-h post-deprivation period; the level of AMPA glutamate receptors increased on the background of sleep deprivation and decreased during the post-deprivation period. These data are assessed in terms of the dynamics of changes in immunoreactive vasopressin levels in the supraoptic and paraventricular nuclei of the hypothalamus in this experiment, as well as in an analogous experiment without blocker administration.