Expression of secretoglobin family 2A member 2 in oral lichen planus lesions

Objective To examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A,MGB1) in oral lichen planus (OLP) lesions.Methods Sixteen OLP patients and 10 healthy controls were included in this study.The real time reverse transcription-PCR (RT-PCR),Western blotting and immunohistochemistry(IHC) were used to determine the mRNA and protein of SCGB2A2.Results Compared with healthy controls (0.48 ± 0.09),the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P ＜ 0.05).However,the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P ＜ 0.05).Conclusions These results suggest that SCGB2A2 may be involved in pathogenesis of OLP. Key words: Lichen planus,oral;  Gene expression;  Secretoglobin family 2A member 2