A novel paradodecatungstate-B compound decorated by transition metal copper, Na 2 Cu 5 (H 2 O) 24 (OH) 2 [H 2 W 12 O 42 ]·10H 2 O: Synthesis, structure and antitumor activities

Abstract A new paradodecatungstate-B compound decorated by transition metal copper, Na 2 Cu 5 (H 2 O) 24 (OH) 2 [H 2 W 12 O 42 ]·10H 2 O ( 1 ), has been synthesized by convenient aqueous solution method and structurally characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis and TGA. The compound crystallizes in the triclinic P -1 space group with a = 10.7140(8) A, b = 12.9476(9) A, c = 13.6696(10) A, α = 73.56°, β = 75.73°, γ = 67.69°, V = 1661.8(2) A 3 and Z = 1. In compound 1 , polyanion of [H 2 W 12 O 42 ] 10 − acts as a dodecadentate ligand that links copper and sodium cations, forming a remarkable three-dimensional framework. The experiment of antitumor activities in vitro shows that the title compound exhibits remarkable inhibitory actions on human cervical carcinoma HeLa cells, ovarian carcinoma SKOV-3 cells, hepatoma HepG2 cells and neuroblastoma SHY5Y cells.